Eicosapentaenoic Acid (EPA) in Reducing Secondary Cardiovascular Events in Hypercholesterolemic Japanese Patients
نویسندگان
چکیده
منابع مشابه
Eicosapentaenoic acid (EPA) reduces cardiovascular events: relationship with the EPA/arachidonic acid ratio.
The clinical efficacy of fish oil and high-purity eicosapentaenoic acid ethyl ester (hp-EPA-E) for treating cardiovascular disease (CVD) has been reported. Fish oil contains saturated and monounsaturated fatty acids that have pharmacological effects opposite to those of ω3 fatty acids (ω3). Moreover, ω3, such as EPA and docosahexaenoic acid (DHA), do not necessarily have the same metabolic and ...
متن کاملEffects of eicosapentaenoic acid on cardiovascular events in Japanese patients with hypercholesterolemia: rationale, design, and baseline characteristics of the Japan EPA Lipid Intervention Study (JELIS).
HYPOTHESIS The principle aim of the current study is to test the hypothesis that the long-term use of highly purified EPA (eicosapentaenoic acid: 1800 mg/day), in addition to HMG-CoA reductase inhibitor, is effective in preventing cardiovascular events in Japanese patients with hypercholesterolemia. BACKGROUND Epidemiological and clinical evidence suggest that intake of long-chain polyunsatur...
متن کاملClinical and epidemiological study of eicosapentaenoic acid (EPA) in Japan.
Between 1978 and 1980, we investigated and compared the dietary intake of fish meat, platelet function, rheological properties of blood and mortality rate due to thrombotic cardiovascular diseases between the residents of fishing and farming villages. Notable finding is that the dietary intake of EPA in the residents of fishing village was nearly 3 times (2.5 g/day) higher than that (0.9g/day) ...
متن کاملIncremental effects of eicosapentaenoic acid on cardiovascular events in statin-treated patients with coronary artery disease.
BACKGROUND Results from JELIS (Japan EPA Lipid Intervention Study) demonstrated the efficacy of pure eicosapentaenoic acid (EPA) in preventing coronary artery disease (CAD) in hypercholesterolemic patients under statin treatment. The present study examined in detail whether EPA is effective for the secondary prevention of CAD. METHODS AND RESULTS Patients with established CAD and a total chol...
متن کاملDietary effect of eicosapentaenoic acid (EPA) containing soyphospholipid.
In this study, we evaluated on a comparative basis the dietary effect between eicosapentaenoic acid (C20:5, EPA)- containing soyphospholipid and soyphospholipid without EPA when added at 5% or 10% level by weight in soybean oil as the dietary oil on the proportions of lipid components in serum of rats. Rats were taken in five groups. One group was fed 20% soybean oil. Two groups received soybea...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2009
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-09-0331